Cell Encapsulation Within Alginate Microcapsules: Immunological Challenges and Outlook
نویسندگان
چکیده
منابع مشابه
Co-encapsulation of pancreatic islets and pentoxifylline in alginate-based microcapsules with enhanced immunosuppressive effects
Alginate-based scaffolds have received considerable attention for biomedical application because of their biocompatibility and ease of preparation. The application of alginate hydrogels for encapsulation of pancreatic islets is known as a potential treatment for type I diabetes. In this study, dextran-spermine coated microcapsules of alginate containing pancreatic islets were prepared, and then...
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The overall goal of this study was to fabricate multifunctional core-shell microcapsules with biological cells encapsulated within the polymer shell. Biocompatible temperature responsive microcapsules comprised of silicone oil droplets (multicores) and yeast cells embedded in a polymer matrix (shell) were prepared using a novel microarray approach. The cross-linked polymer shell and silicone mu...
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With UF-resin as wall material, chlorpyrifos microcapsules was prepared by in-situ polymerization. The effect factors on the particle size and encapsulation efficiency of microcapsules were investigated and optimized. The result showed when the mass concentration of the emulsifier Tween-20 was 6%, the size of chlorpyrifos microcapsules were suitable. The amount of UF-resin has slight effect on ...
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An alternative approach to somatic gene therapy is to deliver the therapeutic protein by implanting genetically modified cells that could overexpress the gene of interest. Microencapsulation devices were designed to protect cells from host rejection and prevent the foreign cells from spreading while allowing protein secretion. Alginate microcapsules form a semi-permeable structure that is suita...
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Introduction: Improved drug delivery mechanisms for the treatment of residual peritoneal cancer cells following cytoreduction surgery are needed. Alginate microcapsules are a potentially useful mechanism for delivery of bioengineered cells, but when injected into the peritoneum, their distribution and properties are not well described. Methods: Aliquots of 300, 600 or 1200 microcapsules were in...
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ژورنال
عنوان ژورنال: Frontiers in Bioengineering and Biotechnology
سال: 2019
ISSN: 2296-4185
DOI: 10.3389/fbioe.2019.00380